منابع مشابه
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY The heme-heme oxygenase system: a molecular switch in wound healing
When cells are injured they release their contents, resulting in a local accumulation of free heme proteins and heme. Here, we investigated the involvement of heme and its degrading enzyme heme oxygenase (HO) in the inflammatory process during wound healing. We observed that heme directly accumulates at the edges of the wound after inflicting a wound in the palate of Wistar rats. This coincided...
متن کاملThe Heme Connection: Linking Erythrocytes and Macrophage Biology
Erythroid function and development is intimately linked to macrophages. The primary function of erythrocytes is oxygen delivery, which is mediated by iron-containing hemoglobin. The major source of this iron is a recycling pathway where macrophages scavenge old and damaged erythrocytes to release iron contained within the heme moiety. Macrophages also promote erythropoiesis by providing a suppo...
متن کاملInduction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis.
Heme oxygenase-1 (HO-1) plays a key role in protecting tissue from oxidative stress. Although some studies implicate HO-1 in modulating thrombosis after vascular injury, the impact of HO-1 on the rate of clot formation in vivo is poorly defined. This study examined the potential function of HO-1 in regulating platelet-dependent arterial thrombosis. Platelet-rich thrombi were induced in C57BL/6J...
متن کاملQuantification of labile heme in live malaria parasites using a genetically encoded biosensor.
Heme is ubiquitous, yet relatively little is known about the maintenance of labile pools of this cofactor, which likely ensures its timely bioavailability for proper cellular function. Quantitative analysis of labile heme is of fundamental importance to understanding how nature preserves access to the diverse chemistry heme enables, while minimizing cellular damage caused by its redox activity....
متن کاملIncidence of venous thromboembolism in COPD: linking inflammation and thrombosis?
Chronic obstructive pulmonary disease (COPD) is a major health burden and expected to become the third leading cause of death by 2030 [1, 2]. Acute exacerbations with aggravation of respiratory symptoms are associated with an acceleration of progressive lung function decline and significant worsening of prognosis (in-hospital mortality rate, 10%; 3-year mortality rate, 49%) [2]. Management of p...
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine
سال: 2021
ISSN: 2077-0383
DOI: 10.3390/jcm10030427